β-Nicotinamide mononucleotide (NMN) is a nucleotide and can be used as a NAD activator. NAD is a coenzyme responsible for homeostasis and balance in the body. Reducing this coenzyme can affect aging because it balances the effects of all organic systems.
Let’s talk about NMN powder in detail.
What is NMN Powder?
Nicotinamide mononucleotide powder is derived from ribose and nicotinamide. Like nicotinamide riboside (NR), NMN is a niacin derivative. NMN is responsible for NAD+ production. Аnyone that has enzymes can use NMN to make nicotinamide adenine dinucleotide (NADH).
It is present in all cells, and they can utilize it for cell health, metabolism, cell repair, longevity, and many other health conditions.
Physical features:
- Synonyms – β-Nicotinamide monophosphate, β-NMN, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate, NMN, NMN zwitterions, Nicotinamide mononucleotide, Nicotinamide ribotide;
- CAS Number – 1094-61-7;
- Molecular formula – C11H15N2O8P ;
- Molecular weight – 334.221 g·mol−1 ;
- Color – white crystalline powder;
- Solubility – soluble in water, 50 mg/ml in water;
- Purity – 99%;
- Density – 0.5 g/ml;
- Storage – 2-8 °C.
Forms and Specifications
Our NMN product is 99% powder, which is especially known for its use as an anti-aging supplement. It is a high-quality bulk product, stabilized, highly purified, and with high bioavailability. It is third-party tested and comes in a package as 1kg/bag, 25kg/drum.
Тhe shipment is available by FedEx, by Air, by sea, express delivery, UPS, etc.
NAD vs. NMN
As said before, NAD+ is an essential coenzyme required for cellular functions. With age, NAD+ levels naturally decrease in many tissues. The body can’t generate NMN. We need to supplement external NMN, which will play a role as a “precursor” of NAD+.
Simply put: higher NMN levels mean higher NAD+ levels.
NMN vs. NR
Nicotinamide riboside is pyridine–nucleoside, which acts as a precursor to NAD+. It has many potential benefits for health.
The crucial difference between NMN and NR is in their molecular formula, and how the cells synthesize them to NAD+. To have a clearer picture about NR and compare it to NMN, some specifications are listed below:
- CAS Number – 1341-23-7;
- Molecular formula – C11H15N2O5 ;
- Molecular weight – 255.25 g·mol−1 ;
NMN is bigger, so it needs to break down in order to enter the cell. NR has better efficiency, because it is smaller in size, and can increase NAD+ by 60% in humans.
NMN vs. Niacinamide
NMN is a derivative of niacin. NMN is a better molecule because it rises NAD+ levels much more than niacinamide.
NMN and Resveratrol
Resveratrol is a stilbenoid. It is found as a plant compound that acts as an antioxidant. Together with NMN, they are synergistic. Without NMN, resveratrol can’t work effectively. NMN is like a fuel for resveratrol.
Sirtuin genes play a key role in anti-aging. As we age, we have half the NAD than we have in our 20s. So, we need more NAD for energy cell production.
We take resveratrol for increasing the activation of sirtuin genes, and NMN makes sure the genes have enough energy to work.
However, the absorption of resveratrol by the gut is more difficult compared to NMN. If little resveratrol remains in the body, is broken down very quickly.
How Does NMN Powder Work?
NMN boosts NAD+ levels to extend lifespan and promote health. NMN has anti-inflammatory effects, so can lower the levels of inflammation which is more present during aging.
It is well-absorbed by the gut and is the best option to impact aging. In one study, the researchers show that giving 12 months of NMN supplement to mice shows significant anti-aging effects.
NMN Powder Manufacturing Process
There are three ways of producing NMN powder:
Biological enzyme method
NMN is produced by the enzyme called nicotinamide phosphoribosyltransferase (NAMPT). With the help of NAMPT, NMN attaches a phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate).
NMN can also be produced by NR, with the addition of a phosphate group. High levels of NAMPT mean increasing NMN levels, and thus the production of NAD+ will rise.
Fermentation method
NMN produced by yeast fermentation is of high purity. During the process, the results show that yeast is required for the production of NMN.
Chemical synthesis
One way to produce NMN is by Zincke’s reaction. The reaction is N-(2,4-dinitrophenyl)-3-carbamoyl pyridinium chloride with 2′,3′-O-isopropylidene-α/β-D-ribofuranosylamine.
Benefits of using NMN
The anti-aging properties of NMN are not only a result of the increased levels of NAD+ but also a result of the pathways and functions of NMN in the human body.
NMN can contribute several other health benefits, such as:
Heart protection
NMN has shown that significantly protects the heart from ischemia. Giving NMN decreased and normalized the NAD+ levels, 30 minutes after ischemia.
Recent studies claimed that glycolysis provides cardioprotection. During ischemia, NMN stimulates the process of glycolysis and the production of ATP, which contributes to cardioprotection.
NMN treatment improves the use of cardiac energy and normalizes cardiovascular dysfunctions.
Remedy for Intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is a brain injury that causes a hematoma. A single dose of NMN in mice reduces the edema and improves neurological functions.
The treatment with NMN reduces oxidative stress in the affected area. NMN could be a promising agent for curing ICH.
Improves cognitive function
The studies claimed that NMN reduces cognitive hypersensitivity in anxiety and other mental disorders and improves cognitive functions.
NMN can also be good for managing Alzheimer’s disease. Given a single dose of NMN reduces the protein in the mitochondria, which is a part of an important process responsible for cellular survival.
NMN Powder side effects
NMN is safe for use and has no serious side effects.
NMN Powder dosage
The perfect and safe dosage is 500mg.
Where to buy bulk NMN powder
NMN has very high purity, 99%. That means that has also a higher bioavailability. It is soluble in water, 50 mg/ml in water. The bulk product comes in a package as 1kg/bag, 25kg/drum. NMN powder is a white crystalline powder used in cosmetics, medicines, and supplements.
Advantages
- Our product is third-party tested, which means it meets certain standards in the manufacturing process;
- We manufactured high-quality powder with more than 99% purity;
- It is a safe and non-toxic product;
- NMN molecules are usually unstable and must be kept in a cold refrigerator. But our powder is in a completely stable form at room temperatures.
If you want to know more, get technical documents such as COA (Certificate of analysis), MSDS, request a quote, we are ready to talk!
