Fisetin powder, an active ingredient from wax tree extract(Rhus Succedanea or cotinus coggygria), is a senolytic flavonoid that is believed to support brain health as a nootropic and also promote healthy aging. Fisetin’s passage across the blood-brain barrier allows it to remove senescent cells in your brain, which may improve memory and cognitive function.
The recent studies are more focused on its medical potential. Besides anti-aging and longevity effects, it can improve heart function, inhibits prostaglandins, help in surgical infections (osteomyelitis, acute tonsillitis, external otitis).
What is fisetin?
Fisetin is a flavonol, from the polyphenols group, naturally found in many fruit and vegetables. It is considered a plant pigment that gives characteristic properties to many fruits and vegetables, such as distinctive color and appearance.
Fisetin shows anticancer, anti-inflammatory, antioxidant activity, and also improves memory.
Let’s take a look at its certain specifications:
- Synonyms – Cotinus Coggygria P.E., Rhus succedanea stem, Buxus Sinica, Wax Tree Extract, Superfustel, Fisetholz, Viset, etc;
- CAS number – 528-48-3;
- Molecular formula – C15H10O6 ;
- Molecular weight – 286.2363 g/mol;
- Color–yellow crystal powder;
- Solubility –insoluble in water, chloroform, n-hexane, soluble in methanol, ethanol alkaline;
- Purity – 98%;
- Storage – cool dry place.
You can also find it by its brand name Novusetin and Cognisetin.
Fisetin vs. Quercetin
Quercetin is also flavonol used as a coloring agent for many plants. It has anti-oxidative and anti-inflammatory effects that help in many health conditions such as controlling blood sugar, killing cancer cells, preventing heart disease, and many more.
Quercetin has five hydroxyl groups in the structure, compared to fisetin which has four hydroxyl groups. Another difference is that fisetin has twice as senolytic potency as quercetin. Let’s take a look at the quercetin specifications for better comparison:
- Synonyms – 5,7,3′,4′-flavon-3-ol, Sophoretin, Meletin, Quercetine, Xanthaurine, Quercetol, Quercitin, Quertine, Flavin meletin;
- CAS number –117-39-5;
- Molecular formula – C15H10O7 ;
- Molecular weight – 302.236 g/mol;
They both have low solubility in water and low oral bioavailability. They exhibit synergistic effects together where they inhibit cancer growth and help to enhance anti-cancer drugs molecules.
Fisetin is naturally occurring in a variety of plants such as apples, strawberries, kiwi, cucumbers, grapes, onions, persimmons, lotus root, etc. But it is naturally extracted from the stem of Rhus succedanea, as its main source.
Fisetin forms and specifications
Fisetin powder has two forms, 50% fisetin powder and 98% fisetin powder. They are high-purity powders, standardized and third-party tested. Produced naturally, with the extraction process. They both come in a package as 1kg/bag, 25kg/drum.
Various delivery ways are accepted such as FOB, CIP, CFR, EXW, CIF, Express Delivery, FedEx, etc.
How does fisetin work
Fisetin reduces aging in murine and human adipose tissue. The administration of fisetin in mice has returned the homeostasis, reduced age-related pathology, and extended the lifespan. Also, has reduced the aging markers through the senolytic mechanism of action.
Furthermore, it blocks the NF-kB pathway, which produces inflammatory compounds that will cause cancer, allergies, and autoimmune diseases.
Fisetin manufacturing process
One way of fisetin powder production is by extracting fisetin from wild lacquer. The steps involved in this method are as follows:
- pulverize wild lacquer wood sticks with pulverizer, add sodium hydroxide solution to soak 1-2 hours. Take it out and let the leaves dry until are 10-15%.
- add ethanol to the leaves, and heat to react at 180-220°C;
- after 2.5 hours, cool to room temperature and collect the material from the reaction. Filter it;
- concentrate the filtrate until the total liquid is 23-25%;
- Add water to this concentrated solution for fisetin to precipitate, and then obtain it.
With this method, high quality and high purity fisetin is obtained, and ready for industrial production.
For the detailed manufacturing process and raw materials used, please send inquires to us directly. We’ll reply to you within 8 hours.
As a part of flavonoids, fisetin has been reported to have many health benefits, which we are going to discuss further. A wide range of health benefits include:
Acts as antioxidant
Researchers indicate that fisetin is a powerful antioxidant. Fisetin has the ability to fight free radicals, and neutralize them because they can contribute to additional health problems.
As an antioxidant, it supports the immune system, increases GSH, and maintains mitochondrial function.
Anti-aging and longevity properties
Many studies claim that fisetin can extend lifespan in mice. It can block the mTOR pathway, responsible for aging. It can reduce inflammation by inhibiting the inflammatory enzyme, which can cause oxidative stress and accelerate aging.
Giving fisetin in older humans was shown to extend health and lifespan.
Support cognitive function and memory
Fisetin has a positive impact on brain functioning because can improve cognitive function and memory. It can be used for patients that have memory disorders because it was shown that fisetin enhances long-term memory.
Studies imply that giving fisetin in mice with Alzheimer’s has improved cognitive function. Fisetin has beneficial effects on brain cells. It is a small molecule that can easily cross the blood-brain barrier. In the brain, it supports the removal of aging cells. By selectively removing aging cells (and the spread of inflammation they trigger), fisetin can improve overall brain function and help restore mental alertness.
Fisetin side effects
Giving fisetin has shown to have no side effects, even given at high doses.
The perfect dosage is 100mg.
Where to buy bulk fisetin powder
The fisetin powder is tested by accredited third-party labs to ensure purity, identity, and potency. It comes in 1kg/bag, 25kg/drum as a high-quality and purity compound. About the storage, you should store the package in a cool and dry place.
From full formula development, dosage analysis, to formula evaluation and testing, resulting in a pure Fisetin 98% powder.
- Third party tested;
- Non-toxic and safe to use;
- Meets the standards of the manufacturing process, according to GMP.
To receive a document of these test results, or want to know additional information about the package, prices, shipping, please send us an inquiry.
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