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Rapamycin Powder: a Novel longevity Ingredient that Promotes Lifespan and Anti-aging Benefits

rapamycin longevity

Aging is a risk factor for many diseases such as cardiovascular disease, stroke, certain cancers, or Alzheimer’s. Rapamycin powder is a protein that appears to have a positive effect on aging and is important for healthy cell growth and protein production. Rapamycin and its derivates are well-known for their anti-cancer and immunosuppressive properties. They stop the normal growth of cells in T-cells that are responsible for programming cell death, and which are abundant in the elderly. Also, the inhibition of mTOR with rapamycin prolongs lifespan by 10-20% in mice.

What is rapamycin?

Rapamycin is produced by microbes that live in the soil of Easter Island. Scientists say this discovery is a big step towards prolonging human life. The drug rapamycin is already used in the treatment of patients who have had organ transplants, in order to prevent foreign body rejection, also in heart surgery, and its effect against cancer is being tested.

Other terms referring to rapamycin are Sirolimus, Rapamune, CAS 53123-88-9, ABI-009, etc. You can also find it by its brand name as Rapamune. The CAS number of rapamycin is 53123-88-9. It has a molecular formula of C51H79NO13 with a molecular weight of 914.187g·mol−1. Rapamycin appears as white to off-white powder, which is insoluble in water, but soluble in chloroform, acetonitrile, benzyl alcohol, and acetone.

Rapamycin and TOR (Target of Rapamycin)

Rapamycin is a protein that forms a complex and inhibits the mTOR pathway. The target of the rapamycin (TOR) pathway is found as two complexes in the cells, TOR complex 1 (TORC1) and TOR complex 2 (TORC2). Rapamycin interacts with the target of rapamycin (TOR) proteins to inhibit the signaling to a specific target. Because single mammalian TOR protein has been cloned further, it has been termed as mTOR, RAPT (rapamycin target), RAFT (rapamycin and FKBP12 target), FRAP (FKBP12 and rapamycin associated protein), or SEP (sirolimus effector protein). TOR proteins act as a Ser/Thr protein kinase, which means they regulate the biological activity of proteins. Rapamycin has the ability to inhibit mTOR kinase activity.

Rapamycin bioavailability

The bioavailability of rapamycin is 14% as an oral solution. Also, if administrated orally in a form of a tablet, the bioavailability increases to 27%. In addition, the availability of rapamycin is also increased when eating high-fat food.

Rapamycin autophagy

Autophagy is actually the ability of a healthy cell in the body to recycle the waste that accumulates in it and its environment. Fasting, ie starvation, stands out as the main driver of autophagy. Namely, it takes a certain number of hours not to ingest any calories for autophagy to start. Rapamycin suppresses the mTOR pathway, inhibits cell proliferation, and induces autophagy. Rapamycin is used as a therapeutic agent in treating certain diseases with the process of autophagy. mTOR is responsible for cell proliferation, and tumor development. Therefore, rapamycin binds to mTOR to block the pathway and increase autophagy.

Tacrolimus and rapamycin

Tacrolimus is an important medication that acts as an immunosuppressant, and together with rapamycin has synergistic effects in preventing rejection of tissue transplantation.

Tacrolimus is also known as Advagraf, Prograf, Protopic, and others. The CAS number of tacrolimus is 104987-11-3. It has a molecular formula of C44H69NO12 and a molecular weight of 804.031 g·mol−1. Tacrolimus appears as white crystals or crystalline powder and is insoluble in water, but soluble in methanol, acetone, ethanol, etc. The bioavailability of oral tacrolimus administration is 24%, which is lower than rapamycin bioavailability. Tacrolimus absorption is reduced in the presence of food. It is better to be taken during fasting. Taking rapamycin and tacrolimus has certain side effects if administrated in the longterm. Tacrolimus can cause high blood pressure, high blood glucose, mental changes, kidney damage while taking rapamycin can increase triglycerides and cholesterol.

Rapamycin can be a better option because it may have fewer side effects and it is low-cost compared to tacrolimus. It has also higher bioavailability that can be taken with or without food, while tacrolimus is better if is administrated during fasting.

Rapamycin forms and specifications

The rapamycin powder has high purity of 99%. It comes in a 25 kg package size (white kraft carton box or in a paper bag). Keep the product tightly sealed in a cool place and away from direct sunlight. It is a high-purity powder, standardized and third-party tested. The shipment is available through various ways like FOB, CIP, CFR,  EXW, CIF, Express Delivery, FedEx, etc.

How does rapamycin work?

Rapamycin revealed its action by targeting the mTOR pathway. Inhibition of mTOR means blocking the cells from growing further. As an immunosuppressant drug, rapamycin disrupts the cytokines signals that are responsible for the activation of T lymphocytes and their proliferation. Also, rapamycin binds to specific proteins to form the immunosuppressive complex. Therefore, this complex inhibits the mammalian target of Rapamycin (mTOR) and blocks its progression.

Rapamycin manufacturing process

If you want to know about the steps of manufacturing and the raw materials used, contact us for details.

Rapamycin benefits

The benefits that rapamycin offers include:

Anti-aging

Rapamycin recently has become the best compound for anti-aging effects. Rapamycin slows down aging by acting as an immunosuppressant and controlling stress and cellular energy. Recent studies show that rapamycin can make your skin looks younger. The treatment results in increasing collagen levels, a protein that gives the structure of the skin. Moreover, by blocking the cells to grow, rapamycin expands lifespan.

Longevity

Because rapamycin is well known as a potential drug in anti-cancer therapies, it increases lifespan by 9-14% by preventing cancer growth. Many types of research done are focusing on the impact of rapamycin on certain age-related diseases. In addition, rapamycin increases lifespan in mice by 26%. In one study, given rapamycin without food can extend the lifespan of female mice.

Cancer treatment

Rapamycin is used as a potential therapeutic agent for cancer treatment. It inhibits cancer growth by blocking the mTOR pathway. By inhibiting mTOR activation, cells are unable to proliferate. It promotes the immunosuppressant actions to block B lymphocytes proliferation with the same mechanism that blocks cell proliferation.

Rapamycin side effects

There are certain side effects while taking rapamycin, such as nausea, diarrhea, acne, headache, confusion, etc. However, these side effects can be reduced if you take intermittent rapamycin.

Rapamycin dosage

The right dose is age-dependent. However, it is recommended to take 40mg rapamycin daily.

Where to buy bulk rapamycin powder

Hygieia Biotech is a professional wholesale manufacturer that focuses on the production and sales of anti-aging and longevity raw materials. Our Rapamycin 99% powder passed the acute toxicity test, which was actually non-toxic and safe to use. It is third-party tested by institutions (CTI, Intertek, Eurofins) and also meets all the requirements of national standards. As a raw material, it is a highly purified ingredient and has high bioavailability.

If you have any further questions, about the price, how to order, or want to get technical documents such as COA (certificate of analysis), MSDS, quotation, please send us an inquiry.

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