Metformin powder is a therapeutic drug that helps reduce cholesterol and glucose levels in the human blood. Insulin has a direct effect on the deposition of fat in tissues, thus metformin inhibits the sensitivity of the receptors to this hormone. Metformine has other beneficial properties, including slowing down the aging process. The main achievement of this drug, according to the longevity manufacturers, is that it has no side effects with proper use and dosage. Controlling blood sugar can prevent in having kidney damage, heart stroke, blindness, etc, resulting in expanding lifespan. In addition to the positive effect on blood sugar levels, metformin facilitates the work of other organs and systems of the body.
What is metformin?
Metformin powder is the major representative of many biguanides. It is the first-line treatment for type 2 diabetes and is considered the most popular hypoglycemic agent in many countries around the world. Unlike other groups of oral agents, it can help in weight maintenance and weight loss. Metformin is sometimes also used for weight loss (obesity treatment) in people without diabetes but this is not the main purpose. In addition, it does not affect glucose levels in healthy people.
Other terms referring to metformin include metformin HCl, metformin hydrochloride, Glucophage, Fortamet, Glumetza, N, N-dimethylbiguanide, 657-24-9,1115-70-4 (as HCl), and many more. The CAS number of metformin is 657-24-9, and 1115-70-4 as HCl. The chemical formula is C4H11N5, with a molecular weight of 129.167 g·mol−1. It has a white to off-white crystalline powder that is soluble in water, but insoluble in acetone, chloroform, and ether.
Metformin anti-aging David Sinclair
According to David Sinclair, metformin is a very potent drug in treating certain diseases, as well as prolonging lifespan. When we eat processed food and have a sedentary life, our longevity genes are not active. In order for this longevity genes to start doing their job, exercise and the right diet is the first thing to do. Metformine is an interesting anti-aging molecule because it can activate the longevity genes, called sirtuins. Metformin is currently being studied for its anti-aging effects. We can live longer and healthier.
Only a minimum of metformin can reduce blood sugar levels, and increase your life and healthspan. Another great anti-aging molecule is rapamycin powder, but according to David Sinclair, it is less safe than metformin, but very potent as well. Metformine is considered a safe drug, in the group of essential medicines for humanity, according to the WHO. Metformin can prolong life because it interacts with the mitochondria, the place where the energy is made while triggering the cells to produce more energy. This process also activates the genes. The result of this is that the cells are becoming resistant to diseases. The root of all the diseases is aging, which needs to be treated.
Metformin and rapamycin anti-aging
Metformin and rapamycin are both calorie restriction drugs, that block the mTOR pathways. They are anti-cancer and anti-aging drugs that prevent many diseases. Rapamycin is an immunosuppressant that besides its main role used for renal transplantation, it can extend life in multiple animal models. As an anti-aging agent, it can protect the body from other age-related diseases such as cardiovascular diseases, Alzheimer’s, obesity, osteoporosis, arthritis, and others. Metformine also blocks the mTOR pathway but is considered as the first-line treatment of diabetes type 2.
Taken together, rapamycin and metformin can prolong life and healthspan. In vitro, they protect the normal cells in chemotherapy. However, certain side effects are inevitable. Rapamycin can be safe in the short term, but it can have more adverse effects using in a long run. Metformine is considered to be safer than rapamycin.
Metformin longevity study
Metformin has been used for more than 60 years as an anti-diabetic drug. Besides that major characteristic, metformin has been investigated to have effects on aging, lifespan, and healthspan in humans. Metformin activates a protein called AMRK that stores cellular energy in a condition of nutrient deficiency and is also activated spontaneously after physical activity. AMPK produces a cascading effect by regulating two proteins, Raptor and TSC2, which in turn block the central growth protein complex called mTORC1. These findings explain the ability of metformin to inhibit tumor cell growth. By all these actions, metformin can prolong lifespan and can healthy slow down aging.
Berberine vs metformin anti-aging
Berberine quaternary ammonium salt can be obtained from many different plants, including a group of shrubs called barberry. Technically, it belongs to a group of compounds called alkaloids. Berberine lowers blood sugar, provides weight loss, and improves heart health. It is one of the few dietary supplements that are just as effective as a pharmaceutical drug.
Other terms for berberine include umbellatine, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, Berberine Complex, Berberine Sulfate, and more. It has a CAS number of 2086-83-1. Its chemical formula is C20H18NO4+, with a molecular weight of
336.366 g·mol−1. It appears as a yellow solid compound that is slowly soluble in water.
Metformine and berberine are both used as alternative treatments for diabetes and anti-aging. They have a lot of things in common, for example, berberine is considered to be an alternative to metformin. Metformine has greater bioavailability and is well absorbed by the body, while berberine has low bioavailability and it is not quite well absorbed.
Metformine is a better option because it has better bioavailability and there are enough relevant studies done for this drug. For berberine, on the other hand, there are not enough studies.
Metformin forms and specifications
Metformin 99% powder has a very high level of purity and is considered to be safe to use. It comes in a 25 kg pack size as a white kraft carton box or paper bag. Keep the product tightly sealed in a cool place and away from direct sunlight. You can buy metformin by various shipments available, such as FedEx, UPS, by air, by sea, and more options.
How does Metformin work
Metformin exerts its actions by blocking the absorption of carbs in the intestines, and by decreasing gluconeogenesis in the liver, which is where the liver produces glucose. This allows the pancreas to reduce insulin production resulting in lower blood glucose and insulin levels, by accelerating the uptake of glucose. This also results in increased insulin sensitivity, which means that the cell’s insulin receptors function better, and increased the absorption of glucose in the muscles.
Metformin manufacturing process
As a start material, 40% of dimethylamine is used. Together with hydrochloric acid salt, they form dimethylamine hydrochloride by a salification reaction. Adding N, N-dimethylformamide as a solvent metformin hydrochloride crude product is formed. By refining, it is obtained metformin hydrochloride. The purity of the final product is very high.
Some of the benefits metformin offers include:
Metformin helps in reducing blood sugar levels by utilizing insulin and reducing insulin resistance (making your body more sensitive to insulin.) Due to lack of energy, the liver responds by making more sugar as fuel, and the pancreas responds by making more insulin. The result is high blood sugar levels and high insulin levels. Metformin helps restore balance by increasing insulin sensitivity and reducing the production of sugar made in the liver.
One of the ways this drug works on weight loss is by reducing appetite. One research has shown that women taking metformin were significantly less hungry. Metformin is thought to help reduce calorie intake too. Such a gradual, slight change in the feeling of hunger can help with easier weight control in the long term.
Metformin reduces age-related diseases. Because metformin effectively reduces both blood glucose and blood insulin levels, it also lowers the risk of many chronic degenerative diseases. Therefore, in addition to its use in the treatment of type 2 diabetes, metformin is now beginning to be recognized as a therapy to slow down aging. Sugar in the body can combine with proteins and make them non-functional. This process is called glycosylation and it is one of the primary causes of aging. Because metformin lowers blood glucose levels, it reduces glycosylation, which means it slows down the destruction of proteins throughout the body and slows down the aging process.
In previous studies with different animal species, metformin therapy resulted in a significant increase in life expectancy. In one study, diabetics who took metformin had a 54% lower risk of developing any type of cancer compared to those diabetics who did not take metformin. And for people with cancer, metformin users had a much longer survival time. Metformin also activates the longevity genes, called sirtuins, that are important in cellular functions, in DNA repair, and they are strongly associated with longevity.
Metformin side effects
Metformine is generally a safe drug, with some side effects such as nausea, bloating, diarrhea, upset stomach, vomiting, constipation.
The best dose is 0.5 – 2.0 g per day, and you can take it either once or twice a day.
Other longevity ingredients
Talking about anti-aging and longevity supplementation, another great supplementation that helps in the process of aging and prolongs health and life span are NMN (Nicotinamide Mononucleotide), NR (Nicotinamide Riboside), Spermidine, NAD (Nicotinamide adenine dinucleotide), and other anti-aging supplements available on the market.
However, Hygieia Biotech offers a variety of anti-aging and longevity ingredients as raw materials for industries like dietary supplements, cosmetics, and pharmaceuticals, including NMN pure powder, NR powder, and NAD precursors.