Spermidine Powder: An Anti-aging and Longevity Supplement

Spermidine Trihydrochloride powder

Spermidine is a polyamine found in all body cells. As its name suggests, it is found in sperm. Spermidine keeps our cells fresh and healthy by stimulating the process of self-cleaning. The spermidine levels in our body begin to decline with age so it is recommended to replenish them with supplementation. Spermidine has the potential to stop the natural process of cellular aging and to fight diseases that are associated with aging. That’s why spermidine supplementation is important, especially if you are older because our body does not produce enough of it.

What is spermidine powder?

Spermidine is in every cell of our body. The natural spermidine is not actually produced by the cells themselves, but by certain enterobacteria. Approximately one-third of spermidine is produced in the body, while the remaining two-thirds, the significant majority, are absorbed from our food. Spermidine is a natural product, chemically classified as a polyamine.

It was discovered that this great vital substance is not only beneficial for men but can actually be found in all living beings. Spermidine even appears in plant foods, such as mushrooms and legumes, although in smaller amounts.

Other terms referring to spermidine are spermidine trihydrochloride, Spermidine-rich wheat germ extract, N1-(3-Aminopropyl)butane-1,4-diamine, etc. You can also find it by its brand name as SpermidineLIFE. The CAS number of spermidine is 124-20-9 (free base) and 334-50-9 (trihydrochloride).  It has a molecular formula of C7H19N3 with a molecular weight of 145.250 g·mol−1. Spermidine appears as white to off-white powder, which is soluble in water.

Spermidine sources(Foods high in spermidine)

Spermidine is found in many different foods, including mushrooms, legumes, aged cheese, soybean, chickpea, green peas, mango, whole grain products, and wheat germ. Soy contains a particularly high level of this valuable substance and is therefore used to obtain pure spermidine for dietary supplements.

These natural sources, on the other hand, are very low in spermidine concentration, 1%, 2%, or even lower. Therefore, our high-quality spermidine dietary supplement is your best choice if you want to increase your spermidine levels. Our product is with high purity of 99%.

Spermidine forms and specifications

Spermidine trihydrochloride 99% powder is a high purity compound, and it is third-party tested. It has high bioavailability that acts as an autophagy modulator. Spermidine powder as a dietary supplement is a novel ingredient on the market in development. It comes in a package as 1-10 kg/bag, 25 kg/barrel, and you should keep it in a dry place without light. The shipment is available through various ways such as FedEx, UPS, FOB, CFR, CIF, by sea, etc.

Spermidine trihydrochloride vs spermidine

Spermidine trihydrochloride powder has a CAS number of 334-50-9, and the CAS number of spermidine is 124-20-9. Other terms referring to spermidine trihydrochloride include Spermidine hydrochloride N1-(3-Aminopropyl)butane-1,4-diamine trihydrochloride, N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride. It has a molecular formula of C7H22Cl3N3 with a molecular weight of 254.6 g·mol−1. It is a compound that can inhibit neuronal synthetase. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

How does spermidine work

What makes spermidine powder so special is its effect of promoting the natural process of autophagy in the body, which keeps cells fresh and healthy. Studies have confirmed that spermidine is indeed an “elixir of life”, showing that high amounts of the product fight the aging process of cells and promote continuous cell health.

Autophagy act as a cellular trash disposal service. This self-cleaning program helps cells by removing everything from damaged or misfolded proteins to whole organelles and then recycles them. This is an important role because damaged cellular materials negatively affect cell health and in severe cases can cause serious damage.

Spermidine vs NMN

They both are hot ingredients for anti-aging and longevity, but the mechanism of action is different. Spermidine powder helps against aging through autophagy, while NMN powder can have beneficial effects in anti-aging by boosting the NAD+ levels in our body. Spermidine supplementation is a better way to accomplish your goals because autophagy is a natural process that begins to break down and recycle damaged cells.

The CAS number of spermidine is 124-20-9, with a molecular formula of C7H19N3 and a molecular weight of 145.250 g·mol−1. On the other hand, NMN has a CAS number of 1094-61-7, with a molecular formula of C11H15N2O8P and a molecular weight of 334.221 g·mol−1. They are both soluble and stable in water, with high bioavailability.

NMN is produced by an enzymatic process and spermidine is produced by wheat germ extract. However, NMN is a more expensive supplement, while spermidine is cheaper.

Spermidine manufacturing process

Wheat germ is used as a raw material. The wheat germ is dried and stabilized, and the dry matter is reduced in order to obtain a higher spermidine concentration.  With a solid-liquid extraction, a spermidine-rich extract is produced. Throughout the whole process all substances that will cause unwanted reactions are avoided. Only approved ingredients are used. Following quality control, the extract is safe to use without any contamination. The extract obtained contains a high concentration of spermidine. All the raw materials used in the production are observed by the IFS (International Food Standard) and the quality is guaranteed by HACCP plans.

This is the natural extraction method, if you need the synthetic method, feel free to contact us for details.

Spermidine benefits

How to increase the spermidine level in your body? The best way is to take a spermidine supplement, and here are the benefits from it:


Cell aging occurs when the natural process of autophagy, which is the recycling of damaged cells, goes wrong. Spermidine powder, as an autophagy modulator, can be an effective weapon against aging. Spermidine concentration decreases with age. Taking spermidine supplementation is associated with aging and reduces the number of free radicals.


Giving spermidine as a supplement to mice stops the age-related decline in cardiovascular or heart function. Also, spermidine powder increases the overall lifespan by 10%. Research by scientists from the University of Graz has shown that spermidine can slow down the aging process and prolong longevity because it protects cells from damage.

Hair growth

Research has shown that using spermidine powder can promote hair growth. For example, a study of 100 healthy people showed that a spermidine-based dietary supplement prolongs the phase of active hair growth, called the anagen phase. The longer the hair follicle remains in the anagen phase, the longer the hair will grow. Research in test tubes has also shown that spermidine stimulates human hair growth.

Spermidine side effects

No side effects are observed while taking spermidine supplementation.

Spermidine dosage

The recommended dosage of taking spermidine supplementation is 800mg.

Where to buy bulk spermidine powder

Hygieia Biotechnology offers bulk spermidine trihydrochloride 99% powder. The best spermidine supplement powder is with high purity and bioavailability. It is third-party tested, and ready for wholesale. As a raw material, it has passed the toxicity test and was found to be a non-toxic compound. It also meets all the requirements of national standards. Our company as a manufacturing factory offers large stock and wholesale pricing about spermidine trihydrochloride 99% powder.

If you want to get technical documents such as COA (certificate of analysis), MSDS, quotation, please contact us.

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