Ca-AKGCalcium Alpha-Ketoglutarate
The world's first to launch Ca-AKG multi-target anti-aging RCT human clinical trial
U.S. clinical trial registration number: NCT07114536
- CAS402726-78-7
- Scientific EvidenceHuman clinical + animal experiments efficacy verification
- Patented ProcessBiological enzymatic process, exclusive patented technology
- CertificationsCompleted US FDA registration and passed FSSC 22000, ISO 9001, HALAL, and Kosher authoritative certifications
- SafetyDouble tested by Toxicology (SGS) SGS standards
- Industry StandardAlpha-ketoglutarate group standard drafting unit
Supports cellular energy metabolism
Mitochondrial functional homeostasis
Maintain muscle strength and endurance
Bone and joint health
Basic Information
The full name of Ca-AKG is Calcium Alpha-ketoglutarate, and its Chinese name is calcium alpha-ketoglutarate. It is a complex formed by the combination of alpha-ketoglutarate, an important intermediate in the human tricarboxylic acid cycle, and calcium ions. It is involved in cellular energy generation, amino acid metabolism, epigenetic regulation, etc.; it is widely used in the fields of healthy aging, sports nutrition, bone health and special dietary supplements. Studies have shown that it has a positive effect on improving aging-related manifestations, maintaining bone and joint health, and supporting energy metabolism.
01
Product name
Calcium alpha-ketoglutarate (Ca-AKG)
02
CAS number
402726-78-7
03
Molecular formula
C₅H₆CaO₆
04
molecular weight
202.18
05
Purity
98.00%
06
Appearance
White crystalline powder
07
Packaging specifications
1kg/bag; 25kg/barrel
08
Customized ODM services
Available upon request
Calcium Alpha-Ketoglutarate (Ca-AKG) Brand Advantages
Scientific Evidence
Human clinical study: Hygieia has completed a randomized controlled trial centered on EnerLive® Ca-AKG and multiple aging-related targets (ClinicalTrials.gov ID: NCT07114536). This provides clinical evidence for healthy-aging and metabolic-health applications.
Animal studies: Hygieia has also conducted animal studies evaluating EnerLive® Ca-AKG for healthy aging, antioxidant support, and bone and joint health.
Core Patented Technology
Hygieia built the proprietary Zymevolver® directed-evolution enzyme engineering platform. Its green biocatalytic process starts with food-grade L-glutamic acid, generates alpha-ketoglutarate through engineered strains, and uses precisely controlled crystallization to produce Ca-AKG with stable conversion efficiency and no harmful free residues.
Hygieia holds patents covering the Ca-AKG biological preparation process (ZL 2025 1 0494508.X) and a stable AKG crystalline form (ZL202610180392.7), supporting consistent quality for premium-market applications.
Product Applications
Suggested Usage Reference
The recommended daily dose of Ca-AKG is 500–3000 mg/day. The specific addition amount needs to be comprehensively evaluated based on product positioning, dosage form design, target market regulations, compound ingredients, finished product specifications and population needs.
Popular Formula References
- Ca-AKG + Vitamin A + Thiamine + Vitamin B2 + Vitamin B6 + Vitamin B12 + Calcium L-5-Methyltetrahydrofolate
- Efficacy: anti-aging, cell energy, metabolism
Recommended Dosage Forms
capsule
tablet
gummies
PowderApplication Scenarios
The core hub of the TCA cycle
AKG (alpha-ketoglutarate) is the core intermediate of the tricarboxylic acid cycle (TCA cycle). It is located between the two key steps of isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase. It is an important intersection of the metabolism of three major nutrients: sugar, lipids, and amino acids. Its metabolic flux participates in regulating the operating efficiency of the TCA cycle and is a key regulatory node for cellular ATP production. Exogenous supplementation of AKG calcium can be dissociated into α-ketoglutarate in the body, supporting the stable operation of the TCA cycle, helping to optimize the energy conversion efficiency of cells, and providing sustained power support for the body's daily physiological activities.
Dual nutritional support for bone and cartilage systems
Calcium α-ketoglutarate (Ca-AKG) has the dual properties of α-ketoglutarate active component and calcium ion source. The two work synergistically to participate in the homeostasis regulation of the bone and cartilage system. In terms of bone health, AKG serves as an essential co-substrate of prolyl hydroxylase and participates in the biosynthesis of bone matrix collagen; the calcium ions released by dissociation provide a material basis for bone mineralization. In addition, AKG is also involved in regulating bone remodeling-related signaling pathways and supporting age-related bone metabolism balance. In terms of joint care, cell and animal studies have shown that AKG can participate in regulating the microenvironment and matrix metabolism of chondrocytes, support the redox homeostasis of chondrocytes, and help maintain the integrity of joint structures and daily flexibility. This product is suitable for the daily bone and joint nutritional supplement needs of middle-aged, elderly, sedentary and active people.
epigenetic regulation
The aging process is accompanied by systemic changes in epigenetic patterns, in which DNA and histone methylation are the core mechanisms that regulate gene expression. AKG is not only a key metabolic intermediate of the TCA cycle, but also an essential co-substrate of the α-ketoglutarate-dependent dioxygenase family. It participates in reactions related to DNA and histone demethylation, affecting the dynamic regulation of chromatin conformation and gene expression profiles. This mechanism makes AKG a key molecular bridge connecting cellular energy metabolism and epigenetic regulation. Preclinical studies have shown that AKG signaling is associated with aging-related epigenetic remodeling. By maintaining the stability of the epigenetic pattern of chromatin, it helps support the normal physiological functions and vitality of cells.
Quality & Documentation
- Product Specification / TDSRequest
- Eurofins / Third-party Analytical ReportRequest
- Batch Certificate of Analysis (COA)Request
- Safety Data Sheet (MSDS / SDS)Request
- FSSC 22000 & HACCP Food Safety CertificationRequest
- ISO 9001 Quality Management CertificationRequest
- FDA Registration and DMF / Compliance SupportRequest
Contact our team for specifications, batch documents, regulatory support, samples, and quotations.
Request DocumentsFrequently Asked Questions
Q1: What is the difference between AKG calcium (a-ketoglutarate calcium) and AKG (a-ketoglutarate calcium)?
Compared with ordinary AKG (free acid, strong acidity, instability), AKG calcium is neutral, stable, gentler to the gastrointestinal tract, and provides calcium while supplementing AKG, making it a supplement form suitable for long-term consumption.
Q2: Does Hygieia Biotech provide Ca-AKG raw material samples?
Sample support can be provided according to customer needs. Customers can contact Hygieia Biotech to obtain Ca-AKG raw material samples, specifications, COA, TDS, MSDS and quotation plans.
Q3: Does Hygieia Biotech support the development of Ca-AKG ODM formula?
Support. Hygieia Biotech can provide formula design, sample proofing, dosage form development, finished product OEM, packaging solutions and quality document support.
Q4: Is Ca-AKG supported by clinical research?
Hygieia Biotech is conducting human clinical research on Ca-AKG for healthy aging and is registered on the official website of ClinicalTrials.gov with the registration number NCT07114536. The endpoints of the study include inflammatory factor profiles, oxidative stress indicators, metabolomic changes and epigenetic clock correlation assessment. The data has entered the paper compilation and publication stage.
L-Ergothioneine
Calcium L-5-Methyltetrahydrofolate
Pyrroloquinoline Quinone Disodium Salt (PQQ)
NoticeThis content is provided for general physiological metabolism and dietary nutrition education only. It is not medical efficacy advertising and does not replace medication or professional medical care.
Need ingredients or a custom solution?
From sample requests to OEM / ODM customization, Hygieia provides high-purity ingredients and integrated solutions.