21593-77-1
C₆H₁₁NO₂S
161.22
L-configuration
White to off-white crystalline powder
Available upon request
Natural Origin Traceability: S-allyl-L-cysteine (SAC) is the signature water-soluble sulfur-containing amino acid in Aged Garlic Extract (AGE). Fresh garlic contains almost no SAC; through a long aging process, allicin decomposes and recombines to form stable S-allyl-L-cysteine. Unlike the easily decomposable and highly irritating allicin, S-allyl-L-cysteine is the core stable active substance retained after the long-term aging of garlic.
S-allyl-L-cysteine and S1PC (S-1-propenyl-L-cysteine) are structural isomers, both belonging to the characteristic active components of aged garlic, and are currently the most thoroughly studied garlic-derived active molecules in the fields of dietary supplements and cellular health.
Relying on its self-developed Zymevolver® engineering evolution platform, Hygieia Biotech utilizes a green biosynthesis process for the large-scale preparation of high-purity S-allyl-L-cysteine, providing stable, high-purity S-allyl-L-cysteine raw materials and one-stop ODM solutions for global dietary supplement, functional food, and cosmetic formulators.
II. Core Physicochemical and Pharmacokinetic Characteristics
1. High Oral Bioavailability
Rapidly absorbed in the intestine after oral intake, with animal experiments confirming its bioavailability advantage; metabolized in vivo mainly through the N-acetylation pathway, and metabolites are mildly excreted via the kidneys.
2. Metabolic Safety Advantages
S-allyl-L-cysteine has almost no inhibitory effect on the human cytochrome P450 enzyme system and presents no metabolic conflict when compounded with most nutritional raw materials, making it highly suitable for formulation development.
3. Outstanding Chemical Stability
No volatile sulfides, no pungent garlic odor; tolerates conventional tableting, hard capsule, and powder production processes; requires mild storage conditions and offers an extended shelf life for finished products.
4. Controllable Chiral Purity
The product strictly controls the single chirality of the L-configuration, eliminating racemic impurities to ensure the consistency of biological activity.
III. Biological Mechanisms Verified by Published Research
Extensive global in vitro cellular assays, animal models, and human observational studies show that S-allyl-L-cysteine possesses multiple cellular regulation potentials, with relevant findings published in authoritative journals such as Molecules and the Journal of Agricultural and Food Chemistry:
S-allyl-L-cysteine can upregulate the body’s antioxidant signaling pathways, enhance the expression of antioxidant proteins such as HO-1 and SOD, scavenge reactive oxygen species, mitigate oxidative stress damage, and maintain cellular mitochondrial homeostasis.
By moderately regulating the NF-κB signaling pathway, it reduces the excessive release of pro-inflammatory cytokines (IL-6, TNF-α) and supports the body in maintaining a healthy, balanced inflammatory state.
S-allyl-L-cysteine supports vascular endothelial health, activates the eNOS pathway to promote nitric oxide production, and assists in improving peripheral microcirculation; it also helps regulate lipid metabolism.
Demonstrated in blood-brain barrier-related models to mitigate oxidative damage to neurons; research focuses on cognitive maintenance and neuronal health for middle-aged and elderly demographics.
Alleviates xenobiotic-induced oxidative damage to liver cells, supports normal liver metabolic functions, and is widely applied in liver protection nutritional formulas.
Balances innate immune responses and supports intestinal mucosal immune health, frequently applied in comprehensive immune maintenance formulation solutions.
IV. Core Advantages of Hygieia Biotech S-allyl-L-cysteine Raw Material
✓ Zymevolver® Green Biosynthesis Process
- Distinct from traditional plant extraction;
- Stable raw material purity ≥99.0%, tested by HPLC, with a clear impurity profile;
- Large-scale mass production, stable delivery times;
- Biocatalysis ensures extremely low organic solvent residues, complying with European and American dietary ingredient standards;
- Zero pesticide residues, no risks of plant-derived exotoxins.
✓ Comprehensive Global Compliance
Each batch comes with a full set of testing reports (COA); production lines follow GMP management; aligns with FSSC 22000 and ISO 9001 standards, supports Kosher and HALAL certification consulting, and is suitable for US dietary supplement (DSHEA), and EU food ingredient declarations.
✓ Strict Full-Chain Quality Control
Batch-by-batch testing for: Assay, optical rotation, microbial limits, moisture, residue on ignition, and related substances; supports SGS and Eurofins third-party re-testing, and provides complete traceability documents.
✓ Flexible ODM Customization Services
- Bulk Raw Material Supply: High-purity S-allyl-L-cysteine powder
- Compound Formulation Development: S-allyl-L-cysteine synergistically blended with S1PC, Ca-AKG, PQQ, NMN and other anti-aging ingredients
- Finished Product Manufacturing: One-stop development for powders, hard capsules, tablets, and chewable supplements
- Technical Support: Literature materials, compliance copywriting guidance, and overseas registration consulting
V. Mainstream Application Areas
| Dietary Supplements | Comprehensive anti-aging for middle-aged and elderly, cardiovascular and cerebrovascular care, liver protection, cognitive health, and antioxidant compound capsules/powders. |
| Functional Foods & Beverages | Antioxidant functional powders, sports nutrition foods, microcirculation support beverages. |
| Cosmetic Active Ingredients | Antioxidant serums, early anti-aging skincare products, ameliorating skin oxidative stress, maintaining dermal matrix stability (topical grade specifications can be customized). |
| Scientific Research Reagents | Providing high-purity S-allyl-L-cysteine for university and research institute pharmacological experiment R&D procurement. |
VI. Extension: S-allyl-L-cysteine (SAC) vs S1PC
The market frequently compares the two core components of aged garlic:
- S-allyl-L-cysteine (SAC): Long research history, massive literature volume, mature commercial application, focusing on antioxidation, cardiovascular, and liver care.
- S1PC (S-1-propenyl-L-cysteine): An emerging hot molecule in recent years, with Cell Metabolism studies revealing its adipose-hypothalamus-muscle axis regulation potential, focusing on muscle health and frailty interventions.
Their action pathways are highly complementary. Currently, high-end aged garlic extract products commonly use an SAC + S1PC compound formula. Hygieia Biotech supplies both high-purity S-allyl-L-cysteine and S1PC raw materials and supports customized complex formulations.
Hygieia Biotech focuses on the R&D and production of synthetic biology active nutritional ingredients. Relying on the Zymevolver® strain and enzyme evolution platform, we continuously expand our anti-aging innovative raw material matrix, with products including Ca-AKG, NMN, PQQ, S1PC, S-allyl-L-cysteine, etc. We are committed to using green biomanufacturing technology to provide the global health industry with scientific, stable, and cost-effective active ingredients and integrated ODM solutions. Global brands, raw material distributors, and research institutions are welcome to negotiate sample requests and long-term partnerships.
