L-Ergothioneine
Ergothioneine is a rare natural sulfur-containing amino acid, known as "antioxidant gold", and is mainly concentrated in mushrooms and other fungal foods. Focusing on cellular antioxidant and oxidative stress management, it supports mitochondrial health and cell homeostasis maintenance, and is suitable for anti-aging nutrition, oral beauty and high-end functional food development.
- CAS497-30-3
- Product QualityActual measurement by CTI, Intertek, Eurofins and other international institutions
- SafetyToxicological safety assessment
- CertificationsFSSC22000, ISO9001, HALAL, Kosher authoritative certification
Basic Information
Ergothioneine (EGT) is a sulfur-containing amino acid derivative that naturally exists in mushrooms, beans, oats and other foods. The human body cannot synthesize it by itself and requires external supplementation. It accurately enters cells through the exclusive channel OCTN1 and shows excellent potential in antioxidant defense, mitochondrial protection and healthy aging support. It is widely used in oral nutritional supplements, functional foods, high-end skin care products, etc.
Product Applications
Suggested Usage Reference
The application reference range of ergothioneine oral anti-aging formulations can be designed around 5-30 mg/day. The specific addition amount needs to be comprehensively evaluated based on product positioning, dosage form design, compounding plan, target market regulations, finished product specifications and stability requirements.
Popular Formula References
- Ergothioneine + Vitamin C + Glutathione
- Efficacy: Antioxidant protection, skin health, cell protection
Recommended Dosage Forms
Application Scenarios

Precise cell protection
Ergothioneine is a natural active nutrient with an exclusive targeted transport mechanism in the human body. Relying on the unique OCTN1 transporter in the body, it can accurately penetrate cell membranes and reach the core areas of mitochondria and nuclei. It is different from ordinary antioxidant substances that only act on the surface of cells. It can stay in the core of cells for a long time, effectively remove highly damaging reactive oxygen species generated by the mitochondrial respiratory chain, protect the mitochondrial membrane structure and mitochondrial DNA integrity, and at the same time resist oxidative damage to nuclear DNA, build a protective barrier from the deepest layer of the cell, stabilize the basic physiological structure of the cell, and reduce cell loss caused by endogenous metabolism and exogenous stimulation.

endogenous antioxidant defense
Ergothioneine not only has direct antioxidant capacity, but can also activate the body's Nrf2 endogenous defense signaling pathway, upregulate the expression of HO-1, NQO1 and other antioxidant enzymes, enhance the body's own antioxidant reserves, and form a dual defense system of "exogenous clearance + endogenous activation". Compared with ordinary antioxidant ingredients, its effect is more stable and long-lasting, and it is not easily consumed by metabolism. It can continuously inhibit lipid peroxidation, relieve chronic oxidative stress in the body, balance cellular redox homeostasis, and maintain the body's youthful physiological defense state for a long time.

neurocognitive care
Ergothioneine can be specifically concentrated in nervous tissue, mildly regulate the inflammatory response of the nervous system, and inhibit low-grade inflammatory damage and oxidative degeneration of nerve cells. It can relieve metabolic stress in the brain, maintain brain nerve cell activity and normal metabolic circulation, delay the natural decline of neurological function that occurs with age, help maintain the brain's cognitive status, memory and neural response sensitivity, provide long-lasting, gentle special nutritional care for the central nervous system, and meet the daily maintenance needs of middle-aged and elderly people for neurological health.
Quality & Documentation
- Product Specification / TDSRequest
- Eurofins / Third-party Analytical ReportRequest
- Batch Certificate of Analysis (COA)Request
- Safety Data Sheet (MSDS / SDS)Request
- FSSC 22000 & HACCP Food Safety CertificationRequest
- ISO 9001 Quality Management CertificationRequest
- FDA Registration and DMF / Compliance SupportRequest
Contact our team for specifications, batch documents, regulatory support, samples, and quotations.
Request DocumentsFrequently Asked Questions
Q1: Does Hygieia Biotech provide ergothioneine raw material samples?
Sample support can be provided according to customer needs. Customers can contact Hygieia Biotech to obtain samples, specifications, COA, TDS, MSDS and quotation plans.
Q2: Does Hygieia Biotech support the development of ergothioneine ODM formula?
Support. Based on customer product positioning, dosage form requirements, and target markets, Hygieia Biotech can provide formula design, sample proofing, dosage form development, finished product OEM, and quality document support in the directions of cellular antioxidants, oral beauty, brain health, and healthy aging.
Q3: How to get a quotation?
Customers can submit information such as target product direction, dosage form, expected addition volume, procurement specifications, target market, order quantity and whether ODM services are needed, and Hygieia Biotech will provide customized quotation plans based on needs.
NoticeThis content is provided for general physiological metabolism and dietary nutrition education only. It is not medical efficacy advertising and does not replace medication or professional medical care.
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