As we already know, there are several NAD+ precursors, important for raising the energy levels in our body. One of them is nicotinamide mononucleotide (NMN). This article is all about the NMN dosage you should take daily. It is present in all cells and tissues in the body. Over the years, people will gradually feel the pain that years have brought, frequent straining of the joints, weakness of the limbs, and a decrease in energy. To solve these problems, researchers were working on a new and more efficient high-quality product. Taking NMN can help with age-related conditions such as Alzheimer’s, cardiovascular disease, and many other degenerative conditions.
What is NMN and what does it do in the body
NMN stands for Nicotinamide Nucleotide. Nicotinamide mononucleotide is a compound derived from ribose and nicotinamide. Like nicotinamide ribose (NR), NMN is a derivative of niacin. Human enzymes can use NMN to produce NAD+. It is an NAD+ precursor, which is an important cofactor of longevity proteins in the human body. Some findings show that NMN help in the prevention of anemia. Ischemic preconditioning (IPC) is a term that refers to the protection of tissue from anemia and cardiac ischemia. IPC stimulates SIRT1, a NAD-dependent sirtuin that helps blood flow through the body. Because NMN activates SIRT1, it has the ability to simulate IPC, thus protecting the heart from anemia and arterial blockages.
NMN occurs naturally in human cells and is responsible for NAD+ biosynthesis and energy production. As you age, these two compounds start to decline, leading to stem cell regression. Remember, these cells need enough fuel to replicate constantly, and therefore, a significant decline will reduce cell life. Managing effective anti-aging drugs such as NMN will reverse the process and delay the mechanism of aging. It is one of the best anti-aging supplements.
One of the revolutionary discoveries of Dr. Sinclair focused on the effectiveness of NMN in boosting muscle strength. According to his studies from 2013 and recent 2018, old mice exposed to seven days of NMN treatment became more physically fit and active.
NMN also promotes normal brain function and prevents neurological diseases. Not enough oxygen in the brain can lead to serious consequences. Fortunately, NMN helps the brain to receive all the oxygen it needs. Mitochondrial dysfunction can lead to neurodegenerative diseases, such as Alzheimer’s. Having healthy and active mitochondria can help protect against such diseases. Studies have shown that NMN may be a protective agent against neurodegenerative diseases due to increased NAD+ and mitochondrial activity.
Another benefit is that NMN fights obesity and diabetes. In one study, NMN was used as a treatment of NAMPT deficiency in diabetic mice. The researchers found that NMN stimulates NAD+ biosynthesis and increases NAD+ levels in the pancreas, liver, and adipose tissue. The pancreas is directly responsible for secreting insulin to control blood sugar levels, which we can assume will help prevent diabetes. It has been found that NMN can reduce the impact of potential causes of diabetes, significantly improve glucose tolerance and insulin sensitivity, and thus contribute to the prevention of diabetes and obesity.
How much NMN should I take per day and how often
A higher dosage doesn’t mean better results. The recommended dosage is to take 500mg once per day if you are an adult. For the elderly, the NMN dosage can be up to 1000mg per day for better effect.
Nicotinamide riboside dosage
Nicotinamide riboside (NR) is a nicotinamide nucleoside that functions as a precursor to nicotinamide adenine dinucleotide (NAD). NAD is an important coenzyme involved in many cellular processes, including metabolism, cell signaling, and DNA repair. NR supplements are becoming increasingly popular as a means of boosting NAD levels and supporting optimal health. The recommended dosage of NR depends on several factors, including age, weight, and health status. However, most experts agree that a daily dose of 250-500 mg is safe and effective for most people. For those seeking to maximize the benefits of NR, taking higher doses may be necessary. Speak with your healthcare provider to determine the best dosage for you.
When is the best time to take NMN?
It is recommended to take it in the morning because also it can give you more energy for the day.
How long will it take for me to see results from taking NMN
The complete benefits of taking NMN can be seen after several months. However, the first results usually take 2-3 weeks.
David Sinclair NMN dosage
The Harvard professor, David Sinclair, takes 1g of his NMN per day, in the morning together with resveratrol and trimethylglycine with no side effects. He usually puts NMN in his yogurt, for better effect.
NMN fertility dosage
David Sinclair in one study found that NMN not only increases energy and metabolism but also can increase fertility in women. NMN was administrated to 12 to 14-month-old mice. In general, the fertility in female mice starts to decline when they are 8 months old. The mice that consumed NMN have restored their egg cells, their quality, and the quality of blastocysts as well as enhanced the ovulation rate. The NMN dosage that improves fertility was 500 mg/kg.
NMN sublingual dosage
The recommended NMN sublingual dosage is between 100 and 200mg under your tongue.
NMN trial dosage
Human trials found that an NMN dosage of up to 500 mg per day is effective with no adverse effects. One study shows that NMN exerts its effects if taken 250mg orally NMN. In another finding, NMN has provided effects even at a lower dosage. The dosage ranges between 200 and 500mg per day.
What are the side effects of taking too much NMN?
During the studies, there were no adverse effects recorded in mice and humans. Also, the results show no toxicity, so taking oral NMN supplementation is safe for use.
How can I tell if I’m taking too much NMN?
Taking NMN is safe even at a high dosage of up to 1000mg per day. However, in much higher concentrations, some people can experience possible side effects such as nausea, diarrhea, abdominal pain, itching, and similar.
Can NMN be taken long-term or is it only safe for short-term use
Studies found that NMN can be safe in long-term use for up to 24 weeks. Therefore, you can take NMN both short and long-term. Of course, the results are visible after several weeks of use.
Are there any interactions with other supplements or medications that I should be aware of
According to the studies done in mice, NMN does not interact with other supplements or medication. Also, David Sinclair is taking NMN together with other supplements without side effects.
NMN dosage for dogs
Many dog owners have turned to nmn for their pets, looking for ways to improve their health and increase their longevity. But figuring out the right dosing can be challenging since nmn affects different individuals in different ways.
Some experts recommend starting with smaller doses and adjusting incrementally as needed. It’s also important to try to find the right balance between nmn and other nutrients that your pet may be taking since too much nmn can sometimes have negative side effects.
Ultimately, the best way to determine the ideal nmn dosage for your dog is to work closely with a veterinarian who can guide you through the process and offer tailored recommendations based on your pet’s specific needs and health history. With proper care and attention, your furry friend can reap all of the amazing benefits that nmn has to offer!
About us
Shenzhen Hygieia Biotechnology Co., Ltd. focuses on dietary supplements, like NMN powder for various industries. The NMN powder has high purity of 99%. It is third-party testes and fully stabilized. Available formulations include NMN hard capsule, NMN soft-gel capsule, NMN sublingual table, and more.
References
- Mills, K.F., Yoshida, S., Stein, L.R., Grozio, A., Kubota, S., Sasaki, Y., … & Imai, S.I. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell metabolism, 24(6), 795-806. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/
- Bertoldo, M.J., Listijono, D.R., Ho, W.J., Riepsamen, A.H., Goss, D.M., Richani, D., … & Wu, L.E. (2020). NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell reports, 30(6), 1670-1681.e7. https://pubmed.ncbi.nlm.nih.gov/32049001/
- Yoshino, J., Mills, K.F., Yoon, M.J., & Imai, S. (2011). Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell metabolism, 14(4), 528-36. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204926/
- Yoshino, M., Yoshino, J., Kayser, B.D., Patti, G.J., Franczyk, M.P., Mills, K.F., … & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224-9. https://pubmed.ncbi.nlm.nih.gov/33888596/
- Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., … & Itoh, H. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine journal, 67(2), 153-60. https://pubmed.ncbi.nlm.nih.gov/31685720/
