When you compare fisetin vs quercetin, you can see that each one contributes to your health in unique ways. Fisetin helps eliminate old cells and supports brain health, while quercetin reduces inflammation and aids your body in combating illness. Using both fisetin and quercetin together may enhance your anti-aging benefits even further.
| Compound | Key Benefits | Best Use |
|---|---|---|
| Fisetin | Eliminates old cells; supports brain health and longevity | Short high-dose cycles |
| Quercetin | Reduces inflammation; assists with allergies and heart health | Daily use |
| Combined | May provide stronger anti-aging effects | N/A |
The global market for these supplements was valued at $1.12 billion in 2024 and continues to grow rapidly. Hygieia Biotech is a reputable company that can help you understand the effectiveness and safety of fisetin vs quercetin.
Key Takeaways
- Fisetin helps get rid of old cells. This can help you age well and stay strong.
- Quercetin lowers swelling and helps your immune system. It is good to use every day.
- Taking fisetin and quercetin together may give more health benefits. They work well for anti-aging and protecting cells.
- Eat foods with these compounds, like strawberries and onions, to help your health in a natural way.
- Talk to your doctor before you try new supplements. This makes sure they are right for you.
Comparison: fisetin vs quercetin
Key Differences
When you compare fisetin and quercetin, you see they work differently in your body. Both are flavonols, but their chemical makeup is not the same. Fisetin has four hydroxyl groups. Quercetin has five hydroxyl groups. This small difference changes how they act in your cells.
Here is a table that shows how fisetin and quercetin are different:
| Property | Quercetin | Fisetin |
|---|---|---|
| Chemical Structure | Flavonol with 5 hydroxyl groups | Flavonol with 4 hydroxyl groups |
| Natural Sources | Onions, apples, berries, tea, red wine, broccoli, citrus fruits | Strawberries, apples, persimmons, cucumbers, onions, grapes |
| Bioavailability | Lower (1-10%) | Slightly higher |
| Primary Benefits | Antioxidant, anti-inflammatory, antihistamine | Senolytic (removes old cells), neuroprotective |
| Senolytic Potency | Present, but less potent | Strong |
| Supplement Usage | Often with vitamin C or bromelain | Often in liposomal form |
| Common Dosage | 500-1000 mg daily | 100-500 mg daily |
| Side Effects | Well-tolerated; possible headache, tingling, nausea at high doses | Well-tolerated; fewer reported side effects |
Quercetin is great for fighting free radicals and lowering swelling. Fisetin is best known for removing old cells. These old cells can build up as you get older. That is why fisetin and quercetin are important in anti-aging studies.
New studies show fisetin is better at clearing out senescent cells than quercetin. Quercetin does help, but not as much. If you want to fight aging in your cells, fisetin may help more. If you want help with swelling or allergies every day, quercetin might be best.
Fisetin helps older mice keep their muscle and strength by clearing out bad cells. This means fisetin works on aging problems, not just helping healthy young bodies.
Unique Benefits
Fisetin and quercetin are not just about which is better. It is about which one fits your needs. Each one has special benefits.
- Fisetin is a strong senolytic. It gets rid of old cells that do not work well. Removing these cells can help you move better and feel less weak as you age.
- Fisetin also acts like calorie restriction. It turns on pathways that keep your cells healthy, even if you eat normally.
- Quercetin is best at lowering swelling. It helps your immune system and helps with allergies.
- Quercetin is used for its antioxidant powers. It keeps your cells safe from damage by free radicals.
Here is a table that shows what each supplement does best:
| Health Benefit | Fisetin | Quercetin |
|---|---|---|
| Senolytic action | Yes | No |
| Removal of senescent cells | Yes | Less effective |
| Improvement in physical function | Yes | Not specified |
| Mimics calorie restriction | Yes | Not mentioned |
| Strong anti-inflammatory | Potentially better for chronic inflammation | Yes |
| Antioxidant | Yes | Yes |
| Supports immune health | Not specified | Yes |
Pick fisetin if you want to age well and live longer. Pick quercetin if you want to lower swelling or help with allergies. Some people use both to get all the benefits.
- Fisetin works best for clearing old cells and helping you age well.
- Quercetin is best for lowering swelling and helping your immune system.
Both fisetin and quercetin can be part of your supplement plan. Your choice depends on your health goals and what you want to improve. Scientists are still learning new things about how these supplements help you stay healthy.
What is quercetin?
Overview
Quercetin is a plant compound found in many foods. It is part of a group called flavonoids. Flavonoids make fruits and vegetables look bright. They also help protect plants from harm. When you eat foods with flavonoids, your body gets stronger. Quercetin is one of the most studied flavonoids. You can find it in fruits, vegetables, and some drinks. Scientists like to study quercetin because it helps your health in many ways. You can take quercetin as a supplement or get it from food.
Sources
Quercetin is found in lots of common foods. Onions, apples, and berries have a lot of quercetin. Leafy greens and herbs are also good sources. The table below shows how much quercetin is in different foods:
| Source | Quercetin (mg/100 g fresh weight) |
|---|---|
| Apples | 4.01 |
| Asparagus | 14.0 |
| Broccoli | 13.7 |
| Chili pepper | 32.6 |
| Kale | 22.6 |
| Onions | 45.0 |
| Spinach | 27.2 |
| Dill | 79.0 |
| Blueberry | 14.6 |
| Cranberry | 25.0 |
Onions and dill have the most quercetin. If you want more quercetin, eat these foods often. The chart below shows how much quercetin is in each food:
Health Effects
Quercetin helps your body in many ways. It is a strong antioxidant. Antioxidants fight bad molecules called free radicals. Quercetin can lower swelling in your body. It helps your immune system work better. Quercetin also helps your heart stay healthy. It may lower blood pressure and help blood vessels. Some studies say quercetin helps control blood sugar. It may help you keep a healthy weight. Quercetin can also fight viruses and germs.
Here is a list of the main health effects of quercetin:
| Health Effect | Description |
|---|---|
| Antioxidant Properties | Quercetin is a strong antioxidant. It helps stop damage from free radicals. This may help prevent some diseases. |
| Anti-inflammatory Effects | Quercetin can lower swelling in your body. This helps with many health problems. |
| Anti-diabetic Effects | Quercetin helps control blood sugar and fats. It may help people with diabetes. |
| Antiviral Properties | Quercetin can fight some viruses. It may help stop sickness from viruses like dengue and hepatitis C. |
| Cardiovascular Benefits | Quercetin helps your heart and blood vessels. It may lower blood pressure and help blood flow. |
| Anticancer Effects | Quercetin may help stop some cancer cells from growing. |
| Metabolic Benefits | Quercetin may help with weight loss and better health in people who are overweight. |
Tip: Eat lots of colorful fruits and vegetables to get more flavonoids. Quercetin works best when you eat a balanced diet.
What is fisetin?
Overview
You might know about quercetin. Fisetin is another important flavonoid. Fisetin comes from plants. It gives color to fruits and vegetables. Scientists study fisetin for its strong health benefits. Fisetin is found in many foods, like quercetin. But fisetin works differently in your body. Fisetin acts as a senolytic. This means it helps clear out old cells. Old cells do not work well. Removing them helps you age in a healthy way. Fisetin is better than quercetin at removing old cells. Many people use fisetin for anti-aging and cell health.
Sources
You can get fisetin from different foods. Strawberries have the most fisetin. Apples, persimmons, cucumbers, onions, and grapes have less. Eat more strawberries and apples to get more fisetin. The table below shows how much fisetin is in each food:
| Source | Average Concentration (μg/g) |
|---|---|
| Strawberries | 160 |
| Apples | 26.9 |
| Persimmons | 10.5 |
| Cucumbers | 6.5 |
| Onions | 4.8 |
| Grapes | 3.9 |
Foods with lots of quercetin often have some fisetin too. But fisetin is usually lower than quercetin except in strawberries.
Health Effects
Fisetin has many health effects that make it special. Fisetin is a strong senolytic. It helps remove old and damaged cells. This helps keep tissues balanced and healthy. Studies show fisetin can help animals live longer. Fisetin is good for bones and joints. It helps bone health and may help with osteoporosis. Some research says fisetin helps with osteoarthritis. Doctors think fisetin can help after bone surgery.
- Fisetin lowers signs of aging in tissues.
- It helps tissues work better.
- Fisetin makes bones and joints stronger.
- You may heal better after bone surgery.
Fisetin and quercetin both help with antioxidants and inflammation. Fisetin is better at removing old cells. You can use both to help with health and aging.
Health Benefits
Antioxidant
Antioxidants help keep your cells safe from harm. Fisetin and quercetin are strong antioxidants. They fight free radicals in your body. Free radicals can damage tissues and make you age faster. Fisetin works well even in small amounts. Lab tests show fisetin lowers signs of cell aging. It also cuts down bad molecules in human cells. Quercetin is also a powerful antioxidant. It works in different ways inside your cells. Quercetin helps control which cells live or die.
| Compound | Antioxidant Capacity | Mechanism of Action | Clinical Effects |
|---|---|---|---|
| Fisetin | High, like quercetin | Gets rid of old cells, blocks cell death blockers | Lowers aging signs in human cells |
| Quercetin | High, uses other ways | Targets PI3Kδ and BCL-2 proteins | Cuts free radical harm, controls cell death, and cleans |
You get more health benefits if you use both fisetin and quercetin. Each one protects your cells in its own way. Together, they help your body fight stress from bad molecules.
Tip: Antioxidants like fisetin and quercetin help you stay healthy. They may help you age slower.
Anti-Inflammatory
Inflammation can hurt and cause long-term sickness. Fisetin and quercetin both lower inflammation. Fisetin helps with swelling, especially in arthritis and heart problems. Studies show fisetin stops swelling in joint cells. This may help with osteoarthritis. Quercetin also lowers swelling in your tissues. Many people use quercetin for arthritis and other problems with swelling.
You can take these supplements to help with pain and swelling. Their anti-inflammatory powers help people with long-lasting pain.
Senolytic
Senolytic means getting rid of old cells that do not work. Fisetin is very good at this job. It clears away aging cells that cause swelling and slow healing. Scientists say fisetin is much stronger than quercetin here. Quercetin helps a little but is not as strong.
- Fisetin removes old cells and helps you age well.
- Quercetin helps, but it is not as strong as fisetin.
- Fisetin may give you better anti-aging results.
If you want to fight aging in your cells, fisetin works best.
Brain Health
It is important to keep your brain working well as you get older. Fisetin and quercetin both help your brain, but fisetin is special. In animal tests, fisetin stops bad stuff from building up in the brain. It acts as a strong antioxidant and keeps brain cells safe. Fisetin also stops swelling in the brain. It helps with memory and learning.
| Mechanism of Action | Evidence Type | Description |
|---|---|---|
| Stops bad brain build-up | Animal tests | Fisetin stops plaques and tangles from forming in animal brains. |
| Antioxidant power | Animal tests | Fisetin grabs and removes harmful stuff. |
| Less swelling in the brain | Animal tests | Fisetin blocks NF-kB, lowering swelling chemicals. |
| Helps memory and learning | Animal tests | Fisetin boosts memory and learning in studies. |
| Blocks sugar damage | Animal tests | Fisetin lowers sugar damage in mice. |
- Fisetin may help you think better and protect against Alzheimer’s.
- It helps your nerves and lowers the chance of brain sickness.
- Fisetin’s brain benefits come from fighting damage and swelling.
Quercetin also helps your brain, but fisetin works better in studies.
Cardiovascular
Your heart and blood vessels need help to stay healthy. Quercetin is important for heart health. Studies show quercetin lowers cholesterol and bad LDL. It also cuts down swelling markers like C-reactive protein. Quercetin helps blood vessels relax and protects artery walls. These things lower your risk of heart disease.
Recent studies say quercetin helps with cholesterol, blood flow, and swelling. Fisetin may help your heart, too, but scientists need more research. Its antioxidant and anti-inflammatory powers might help your heart.
Note: Quercetin is great for people with high cholesterol or metabolic problems.
Anti-Cancer
You want to lower your chance of getting cancer. Fisetin and quercetin both fight cancer in lab tests. Fisetin stops cancer cells from growing and makes them die. It works against cancers like pancreatic, colorectal, and laryngeal. Quercetin also fights cancer by changing how cells grow and survive.
| Cancer Type | Mechanism of Action | Key Findings |
|---|---|---|
| Pancreatic Cancer | Targets PI3K/AKT/mTOR signals | Stops cancer cells from growing and moving; it makes them die. |
| Colorectal Cancer | N/A | Slows cancer growth in lab and animal tests. |
| Laryngeal Carcinoma | N/A | Shows anti-cancer effects. |
| Mechanism of Action | Effect on Cancer Cells | Key Findings |
|---|---|---|
| Changes EGFR/Akt Pathway | Raises FOXO1 protein levels | Moves FOXO1 into the cell’s center; affects growth and cell death. |
- Fisetin is a strong antioxidant and lowers swelling, which helps stop cancer.
- Quercetin changes important cell signals, helping cells stay healthy.
You can use fisetin and quercetin to help your body fight cancer. Their health powers may lower your cancer risk and help you feel better.
Effectiveness
Scientific Evidence
There is a lot of research about quercetin and fisetin. Scientists test these compounds in labs and on animals. They want to see how they help the body. Here are some important things they found:
- Fisetin removes old cells that do not work. This helps with aging and keeps your brain healthy.
- Quercetin lowers swelling in your body. It helps your immune system and can help with allergies.
- Fisetin works best when you take a lot for a short time. Quercetin is better taken every day.
- If you use both, you may get more anti-aging benefits than just one.
Scientists are still learning how these supplements work together. Many studies say using both fisetin and quercetin gives you more health benefits.
Human Studies
Clinical trials show how fisetin and quercetin help people. The table below lists some important studies:
| Institution | Study Focus | Dosage Protocol | Key Findings |
|---|---|---|---|
| Mayo Clinic | SARS-CoV-2 Response | ~20 mg/kg/day | Fisetin may stop oxygen levels from dropping |
| The Steadman Clinic | Surgical Recovery | 20 mg/kg for 2 days, monthly | Fisetin may help people heal after surgery |
| St. Jude Children’s Research Hospital | Cancer Survivor Health | 20 mg/kg on days 1, 2, 30, and 31 | Fisetin alone vs. Dasatinib-Quercetin combo for survivors |
Fisetin is safe at about 20 mg for each kilogram you weigh. Some studies use less, like 100 mg a day, and still see less swelling. Quercetin is safe even at high doses, up to 2,000 mg a day. People with COPD took quercetin and did not have problems.
Hygieia Biotech says you should follow clinical dosing rules. Always talk to your doctor before you start new supplements.
Real-World Use
Many people take quercetin and fisetin every day. You might notice these common results:
- Quercetin helps with allergy problems, like itchy eyes and a stuffy nose. It does not make you sleepy.
- Both supplements help your heart by making blood vessels work better.
- Fisetin removes old cells, which may help you feel younger and have more energy.
- Fisetin goes into your brain and protects nerve cells from harm.
- Quercetin lowers swelling and helps your immune system.
People often say quercetin helps with allergies and swelling. Fisetin is known for helping with aging and brain health. You can pick the supplement that fits your health needs, or use both for more benefits.
Safety and Dosage
Fisetin Safety
Fisetin is safe if you use it the right way. Animal studies show fisetin does not hurt your genes. Scientists gave animals 50, 100, and 200 mg for each kilogram they weighed. The animals did not get sick or have bad effects. Most people can take fisetin without problems, even at high amounts. You should talk to your doctor before trying new supplements, especially if you take medicine.
- Animal tests show fisetin does not harm genes.
- Safe amounts are 50 to 200 mg for each kilogram.
- No bad effects were seen at these doses.
Quercetin Safety
Quercetin is also safe for most people. Scientists checked it in short and long studies. The table below shows what they found:
| Study Focus | Findings | Doses | Implications |
|---|---|---|---|
| Sub-chronic oral toxicity in mice | No bad side effects | 62–250 mg/kg diet or 12.5–50 mg/kg bw | Shows quercetin is safe for swelling and cancer support |
| Long-term exposure studies | No cancer risk at lower doses | 1.25–5% in diet (up to 50,000 mg/kg) | High amounts may change body functions, but no cancer risk with long use |
You can take quercetin every day for swelling or as part of a healthy diet. If you use high amounts for a long time, be more careful.
Side Effects
Most people do not have trouble with fisetin or quercetin. Some people may get mild side effects, mostly with high doses or if they are sensitive. Watch for these possible problems:
| Supplement | Side Effects |
|---|---|
| Fisetin | Stomach issues like gas or bloating, rare allergies, may mix with some medicines (like blood thinners) |
| Quercetin | Stomach upset, nausea, rare headaches, changes in blood pressure (be careful with medicine) |
Tip: If you feel any side effects, stop taking the supplement and tell your doctor.
Dosage
Pick your dose based on what you want to help. For daily help or small swelling, 100–500 mg of fisetin or quercetin is good. For anti-aging, use fisetin at 20 mg for each kilogram of your weight once a month. For joint pain, you may need 300–600 mg each day. For brain health or to help prevent Alzheimer’s, 500–1,000 mg each day is common. For cancer help, you might need up to 1,200 mg each day, but only with a doctor.
- Daily use: 100–500 mg for general help.
- Anti-aging: 20 mg/kg once a month.
- Joint pain: 300–600 mg each day.
- Brain health: 500–1,000 mg each day.
- Cancer help: Up to 1,200 mg each day with a doctor.
Start with a small dose and go up slowly if you need to. Always ask your doctor before changing your supplements.
Combination Use
Synergy
You might ask if using fisetin and quercetin together helps more. Studies show that taking both can make them work better. When you use these supplements at the same time, your body gets more help fighting cell damage. They also slow down the growth of bad cells. For example, scientists saw that using both stopped cancer cells from spreading in breast cancer tests. This mix also helped wounds heal faster and made it harder for cancer cells to make new groups.
There are other good things when you use both:
- You get better protection from cell damage.
- Cancer may grow and spread more slowly.
- Some nerve pain medicines might work better.
One study found that using both fisetin and quercetin made sperm healthier. Sperm moved better, and there were more of them. This means you can get more health benefits if you use both together.
Interactions
You might worry if it is safe to use both fisetin and quercetin. Experts, like those at Hygieia Biotech, say this is safe for most people. Both supplements help your body age well and protect your cells. They both fight cell damage and swelling. They also help clear out old cells that can cause problems as you get older.
Animal tests show these supplements help your body remove damaged cells. This helps lower the bad effects of aging and sickness. You should always talk to your doctor before starting new supplements, especially if you take other medications. Most people do fine when using both, but checking with a doctor keeps you safe.
Tip: Using fisetin and quercetin together may help you reach your health goals faster, especially if you want to age well or heal better.
Choosing the Right Supplement
For Aging
If you want to age well, you can use both fisetin and quercetin. Experts say these two work well together. Each one helps with a different part of getting older.
- Fisetin helps your body get rid of old cells. This helps your brain and keeps you strong as you get older.
- Quercetin gives your body extra help against damage and swelling.
- Using both can help you stay healthy as you age.
Many people use both supplements to help with many aging problems at the same time.
For Inflammation
If you want to lower swelling, you have good choices. Quercetin is great for helping your immune system and heart. Fisetin also helps by clearing out old cells that cause swelling.
- Quercetin helps your immune system and keeps your heart healthy.
- Fisetin removes old, damaged cells that can cause swelling.
- Using both may give you better protection from getting sick as you get older. They may also help protect you from cancer.
You can pick your supplements based on what you want to help most.
Personalized Advice
Picking the best supplement depends on what you need. Look for products that show what is inside and use good extracts. Some have bromelain to help your body use them better. You might find products that mix fisetin and quercetin with other things like NMN or resveratrol for more help.
- Make sure your supplement is safe by checking for testing and quality labels.
- Always talk to your doctor before starting a new supplement, especially if you are sick or take medicine.
Taking time to pick the right supplement helps you get the best results.
You should pick your supplement based on your health goals and what science says.
- Fisetin is best if you want to age well and keep your cells healthy.
- Quercetin helps your heart and can make allergies better.
- Many experts say using both gives you stronger benefits.
In 2018, Mayo Clinic found fisetin is the strongest natural senolytic.
If you want to feel even better, try a supplement that has both compounds. Always talk to your doctor before you start new supplements. Hygieia Biotech can help you choose safe and helpful products.
FAQ
Can you take fisetin and quercetin together?
Yes, you can take both together. Many experts believe this combination gives you stronger anti-aging and antioxidant benefits. Always check with your doctor before starting new supplements.
What is the best time to take fisetin or quercetin?
You should take these supplements with food to help your body absorb them. Morning or midday works well for most people. Avoid taking them late in the day if you notice any trouble sleeping.
Are there any foods rich in both fisetin and quercetin?
You find both in apples, onions, and strawberries. Strawberries have the most fisetin. Onions and apples give you a good amount of quercetin. Eating a mix of these foods supports your health.
Who should avoid fisetin or quercetin supplements?
If you take blood thinners or have allergies to plant compounds, talk to your doctor first. Pregnant or breastfeeding women should avoid these supplements unless a healthcare provider approves.
How long does it take to see results from these supplements?
You may notice benefits like less swelling or better energy in a few weeks. Anti-aging effects take longer. Consistent use and a healthy lifestyle help you get the best results.