Hygieia Biotech

Best NAD Powder Wholesale Manufacturer and Factory from China

Nicotinamide adenine dinucleotide powder

What is NAD?

Nicotinamide adenine dinucleotide (NAD) is an important protein for cellular metabolism and viability. It acts as a coenzyme and is found in all living cells.

NAD contains two nucleotides connected with their phosphate groups. NAD+ is the oxidized form of NAD. NAD stands for the NAD in general. The main difference is that NAD+ is a charged molecule. 

NAD had certain specifications:

  • Synonyms – beta-Nicotinamide adenine dinucleotide, NAD+, Coenzyme I, Liposomal NAD+, etc;
  • CAS number – 53-84-9;
  • Molecular formula – C21H27N7O14P2 ;
  • Molecular weight – 663.43 g/mol;
  • Color– white powder;
  • Solubility –soluble in water;
  • Purity – >98%;
  • Storage – stable at 4 °C.

NAD forms and specifications

NAD has two forms: NAD+ and NADH. They are the oxidized and reduced form respectively.

NAD 99% powder is soluble in water. It has high bioavailability and purity. It comes in a package as 1kg/bag, 25kg/drum.

NADH powder is white crystalline powder, with 99% purity. It is a strong antioxidant that supports cognitive functions. NADH powder is highly purified and highly bioavailable.

They are both non-toxic and safe for use. The shipment is available through FedEx, UPS, by air, by sea, etc.). Also, they are fully stabilized, and third-party tested.

NAD+ vs. NAD+ precursors

NAD+ is synthesized through five precursors: Nicotinamide Riboside (NR), Nicotinic Acid (NA), Nicotinamide (Nam), Nicotinamide Mononucleotide (NMN), and Tryptophan (Trp).

NAD+ and its precursors are both anti-aging compounds. As our age increases, the NAD+ levels decrease and need to be replenished for our cells.

The NAD+ precursors differ from NAD, because they are different in their atomic structures, and have different pathways for entering the cells and doing their job.

NR and NMN have been shown to be the most efficient precursors for delaying aging effects.

NAD+ stack with TMG

TMG stands for Trimethylglycine, and it is an amino acid derivative. It is found in many food sources such as beets and spinach. TMG is a methyl donor that supports the activity of NAD. The addition of TMG supports methylation. The process of methylation is important for biological functions like cell division, DNA expression, cellular energy metabolism, and many more.

We are having a methyl pool in our body, which we draw on when we want to methylate something.  The main idea of taking NAD+ precursors is to boost NAD+ levels. During this process, a compound called nicotinamide is formed. For this compound to be excreted from the body, we must methylate it. This is when the problem begins. 

We might take all of the methyl groups from the methyl pool, and that’s why the ability of methylation is decreased. This is where TMG takes place. TMG is the most abundant form because it contains three methyl groups to donate. TMG replenished the methyl pool,  acts as an NAD+ booster and promotes longevity.

How does NAD Powder work?

NAD powder increases lifespan. Increasing the NAD+ levels with supplementation like NR and NMN,  extend the lifespan in mice.

Taking NAD+ boosters can help you to prevent age-related diseases. That means having a long and healthy life, which means increasing healthspan.

NAD powder Manufacturing Process

The method for the manufacturing process of NAD powder is by an immobilized enzyme. This method includes 5 steps:

  • cloning nicotinamide-nucleotide adenylyltransferase genes (NMNAT);
  • expressing recombinant NMNAT in E.coli;
  • extracting a crude extract of the recombinant  NMNAT;
  • performing immobilized recombination of the crude extract of the recombinant NMNAT;
  • preparing NAD based on nicotinamide nucleotide and adenosine triphosphate (ATP) by using the immobilized recombinant NMNAT as a catalyst.

For the detailed manufacturing process and raw materials used, please send inquires to us directly. We’ll reply to you within 8 hours.

Benefits of using NAD powder

Replenishing NAD+ levels in the body has shown promising results in many health conditions such as:


As we age the NAD+ levels decrease and scientists think the decrease may cause our cells to work less efficiently over time.  So, increasing NAD+ levels may support how we age and improve our healthspan, the number of years we live in optimal health.

Also,  NAD+ is crucial for regulating the genes that speed up aging. Because NAD+ is essential for every tissue in our body, and it is a key molecule for reversing aging, it is important to maintain youthful and healthy levels of NAD+.

Energy production

NAD+ is required for energy production in every tissue. For example, our brain, immune cells, muscle requires energy. When NAD levels decrease, as do with age, those cells don’t function properly as they do in youth. The analyzes made showed that NAD supplementation can increase the production of ATP and the rate of energy production. The effect of NAD on heart failure is also associated with increased energy production.

We can say that NAD+ has positive effects on healthy energy production.


Despite NAD being crucial for cellular processes, it is also a promising factor in longevity. NAD has positive effects in activating a group of enzymes involved in longevity, called sirtuins.

The results from one study reviled, show that rising the NAD+ levels in the body, increases the lifespan in mice, rats, and worms.

NAD POWDER side effects

Most people that took NAD powder had experienced no side effects when taking in a  small and short-term dosage.


The appropriate and safe dose is 500 mg.

Where to buy bulk NAD powder

Bulk NAD powder is stable with 99% purity. It is manufactured by standards and by many intellectual property rights. From full formula development, dosage analysis, to formula evaluation and testing, resulting in a pure NAD 99% powder.

NAD powder

It has high bioavailability and absorption for cellular repair. It is third-party tested which means the product matches with what’s on the label.

So, if you want to know more about our bulk product, or get information about COA (Certificate of Analysis), shipment options, delivery time, send us an inquiry. We are always available for our buyers!

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