Hygieia Biotech

Apigenin: A Better Approach for Boosting NAD+ levels, compared to the NAD+ precursors

Apigenin boosts NAD as CD38 inhibitor

Apigenin, a natural plant-based supplement found in common vegetables, fruits, herbs, and beverages, has various health benefits due to its anti-cancer and anti-inflammatory effects. Several studies have shown how apigenin can help inhibit cancer cells and how it can be synergized with specific chemotherapy for cancers such as prostate, pancreatic, gastric, and others. Apigenin is especially useful for thyroid cancer. Interestingly, it binds 160 proteins in the body, which proves that it has a wider effect on health.

What is Apigenin?

Apigenin is a natural product that belongs to the flavonoid group and is an aglycone of some glycosides. It affects the development, function, and maturation of the nervous system. Apigenin is one of the most popular flavonoids. In vivo research, show the promising health effects apigenin provides.

Other names referring to apigenin are chamomile, apigenol, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, versulin, 4′,5,7-Trihydroxyflavone, and more. The CAS number of apigenin is 520-36-5 with a chemical formula of C15H10O5 and a molecular mass of 270.240 g·mol−1. Apigenin appears as a solid yellow crystalline. It is insoluble in water, but soluble in ethanol,  and other organic solvents.

Apigenin vs Quercetin

Quercetin is a flavonol that gives plant pigment characteristic properties to many fruits and vegetables. The CAS number of quercetin is 117-39-5, while the CAS number of apigenin is 520-36-5. Quercetin has anti-inflammatory and antioxidative effects and a similar structure as apigenin. The chemical structure of quercetin differs from apigenin due to the addition of a hydroxyl group in carbon 3.

Apigenin in combination with quercetin inhibits melanoma growth in a mouse model in vivo. Also, studies found that in vivo administration of quercetin and apigenin reduces the number of tumor colonies in the lungs. They also significantly reduce thrombin. The bioavailability of orally administrated apigenin is 30%, while quercetin is 20%. Apigenin is a more potent flavonoid compared to quercetin because it can inhibit an enzyme called CD38, which plays an important role in NAD+ levels in the body. Apigenin needs a small concentration for blocking the CD38 enzyme, while quercetin needs a higher concentration to achieve the same effect as apigenin.

Apigenin vs NMN

β-Nicotinamide mononucleotide (NMN) is a nucleotide that acts as a NAD activator. The CAS number of NMN is 1094-61-7, and you can also find it by other names including β-NMN, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate, Nicotinamide mononucleotide, etc. NMN is responsible for NAD+ production, which means higher NMN levels lead to higher NAD+ levels. On the other hand, we should think about increasing NAD+ levels not only with NAD+ boosters. This is important because CD38 consumes NAD, and increases as we age. Furthermore, CD38 degrades NMN, so increasing NAD+ levels with CD38 inhibitors, like apigenin, is a better approach.

Apigenin sources

Apigenin is abundant in many fruits, vegetables, and beverages. Parsley and chamomile tea are particularly high rich sources of apigenin. Other sources are celery, wine, artichokes, oregano, grapefruit, oranges, onions, and many more.

Apigenin forms and specifications

Our product is with high purity of 99% powder. Apigenin is a high-quality bulk product, stabilized, highly purified, and with high bioavailability. It is third-party tested and comes in a package as 1kg/bag, 25kg/drum.

Тhe shipment is available by FedEx, by Air, by sea, express delivery, UPS, etc.

How Apigenin works

Apigenin is a powerful agent that boosts NAD levels. NAD is a molecule used by a lot of different enzymes in our body, especially in those involved in DNA repair and mitochondrial function. We need to assure that these processes are functionating properly. The main problem is as we age, NAD levels decrease and we need to replenish them. Because of that, our body struggles to absorb it and we must take precursors supplementation that will additionally convert themselves into NAD within our body. Therefore, we must consider an enzyme called CD38, which increases as we get older. CD38 prevents NAD from entering the cell by consuming it. Apigenin can directly inhibit CD38, resulting in increased NAD levels.

Apigenin manufacturing process

For the industrial manufacturing process, parts of Matricaria chamomilla, L. are extracted with a water/ethanol solution for 7-8 hours. This extract is evaporated until dry and agitated with ether for up to 24 hours. The precipitate is hydrolyzed with hydrochloride acid in which all the apigenin precipitates are coming as free aglycone. For further purification of apigenin, crystallization from ethanol solvents is prepared.

The synthetic processes of apigenin production involve several steps to produce the final product, apigenin in high yields and purity. If you want to know about the raw materials used in this method for apigenin production, feel free to contact us for details.

Apigenin benefits

Apigenin can contribute several health benefits, such as:

NAD+ booster

As we age, CD38 levels increase and consume all the NAD levels in the body. Thus, reducing the CD38 levels will boost the NAD+ levels in our body. Apigenin, as the most abundant flavonoids, can inhibit the CD38 activation and, by doing so, promote an increase in NAD+ levels.

Cancer fight

According to research, apigenin is a powerful supplement in cancer therapy. It suppresses human cancer in vivo and in vitro by several different biological effects. Also, it can alleviate adverse effects from chemotherapy. Apigenin shows anticancer activities by different signaling pathways. Studies show that it is a powerful anti-cancer agent alone and in combination with other chemotherapeutic agents.


Our sirtuins genes don’t have enough fuel for their activation, because NAD+ levels are decreasing significantly as we age. Without sirtuins genes activation, we won’t have the anti-aging benefits. Inhibition of CD38 activity will boost NAD+ levels and thus will activate the sirtuins genes. That’s why apigenin is a key molecule in the fight against aging.

Weight loss

Apigenin has been shown to reduce fat and enhance lipid catabolism even at small doses. It encourages lipolysis, fights obesity, and thus has positive effects on insulin resistance.

Apigenin side effects

Apigenin is considered safe and non-toxic, consumed even in high doses.

Apigenin dosage

The typical orally administrated apigenin dosage starts with 50mg. The dosage can go higher.

Where to buy Apigenin powder

Apigenin 99% powder is tested by accredited third-party labs to ensure purity, identity, and potency. Hygieia biotech offers everything from full formula development, dosage analysis, to formula evaluation and testing, resulting in a pure Apigenin 99% powder. Apigenin 99% powder is a non-toxic, safe-to-use supplement that meets the standards of the manufacturing process, according to GMP.

If you want to know additional information about the package, prices, shipping, please send us an inquiry.

Leave a Comment

Your email address will not be published. Required fields are marked *

Get a Quote Immediately